Assay Detail
Binding
CHEMBL891178
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships of methoctramine-related polyamines as muscarinic antagonist: effect of replacing the inner polymethylene chain with cyclic moieties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 8.42 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27673 | METHOCTRAMINE | — | 1 | 8.62 |
| CHEMBL242345 | — | — | 1 | 8.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27673 | METHOCTRAMINE | Ki | = | 2.399 | nM | 8.62 |
| CHEMBL242345 | — | Ki | = | 6.026 | nM | 8.22 |