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Assay Detail

CHEMBL891255

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Functional
Antiviral activity against Sindbis virus replication in BHK cells after 12 hrs by XTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Sindbis virus
Cell Type BHK
Confidence 1 — Organism
Curated By Intermediate

Target

Sindbis virus (CHEMBL613725)
Type ORGANISM
Organism Sindbis virus

Publication

Synthesis of dioxane-based antiviral agents and evaluation of their biological activities as inhibitors of Sindbis virus replication.
Kim HY, Kuhn RJ, Patkar C, Warrier R, Cushman M.
Bioorg Med Chem (2007) 15 : 2667 -2679
PubMed 17287124 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 16 4.79 5.47

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL364472 1 5.47
CHEMBL71 CHLORPROMAZINE 4.0 1 5.09
CHEMBL190235 1 4.85
CHEMBL233305 1 4.54
CHEMBL232898 1 4.00
CHEMBL234549 1 -
CHEMBL6966 VERAPAMIL 4.0 1 -
CHEMBL232899 1 -
CHEMBL232692 1 -
CHEMBL233105 1 -
CHEMBL232691 1 -
CHEMBL232500 1 -
CHEMBL232882 1 -
CHEMBL233106 1 -
CHEMBL232900 1 -
CHEMBL233103 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL364472 EC50 = 3400.0 nM 5.47
CHEMBL71 CHLORPROMAZINE EC50 = 8200.0 nM 5.09
CHEMBL190235 EC50 = 14000.0 nM 4.85
CHEMBL233305 EC50 = 29000.0 nM 4.54
CHEMBL232898 EC50 = 99000.0 nM 4.00
CHEMBL234549 EC50 = 1000000.0 nM -
CHEMBL6966 VERAPAMIL EC50 = 1300000.0 nM -
CHEMBL232899 EC50 = 1500000.0 nM -
CHEMBL232692 EC50 = 1400000.0 nM -
CHEMBL233105 EC50 = 1000000.0 nM -
CHEMBL232691 EC50 = 670000.0 nM -
CHEMBL232500 EC50 = 1500000.0 nM -
CHEMBL232882 EC50 = 1000000.0 nM -
CHEMBL233106 EC50 = 460000.0 nM -
CHEMBL232900 EC50 = 250000.0 nM -
CHEMBL233103 EC50 = 1500000.0 nM -