Assay Detail
Binding
CHEMBL891276
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Inhibition of BuChE in rat serum
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Serum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Study on dual-site inhibitors of acetylcholinesterase: Highly potent derivatives of bis- and bifunctional huperzine B.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 4.43 | 5.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL389579 | — | — | 1 | 5.46 |
| CHEMBL389375 | — | — | 1 | 5.06 |
| CHEMBL244230 | — | — | 1 | 4.89 |
| CHEMBL395281 | — | — | 1 | 4.22 |
| CHEMBL397232 | — | — | 1 | 4.20 |
| CHEMBL241856 | — | — | 1 | 4.19 |
| CHEMBL245080 | — | — | 1 | 4.19 |
| CHEMBL395282 | — | — | 1 | 4.18 |
| CHEMBL415423 | — | — | 1 | 4.17 |
| CHEMBL395280 | HUPERZINE A | 2.0 | 1 | 4.15 |
| CHEMBL440054 | — | — | 1 | 4.05 |
| CHEMBL242068 | — | — | 1 | - |
| CHEMBL438305 | — | — | 1 | - |
| CHEMBL245081 | — | — | 1 | - |
| CHEMBL267591 | — | — | 1 | - |
| CHEMBL413241 | — | — | 1 | - |
| CHEMBL413242 | — | — | 1 | - |
| CHEMBL267836 | — | — | 1 | - |
| CHEMBL413243 | — | — | 1 | - |
| CHEMBL413244 | — | — | 1 | - |
| CHEMBL389580 | — | — | 1 | - |
| CHEMBL242755 | — | — | 1 | - |
| CHEMBL263098 | — | — | 1 | - |
| CHEMBL389779 | — | — | 1 | - |
| CHEMBL413170 | — | — | 1 | - |
| CHEMBL267606 | — | — | 1 | - |
| CHEMBL244027 | — | — | 1 | - |
| CHEMBL413018 | — | — | 1 | - |
| CHEMBL413240 | — | — | 1 | - |
| CHEMBL244026 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL389579 | — | IC50 | = | 3480.0 | nM | 5.46 |
| CHEMBL389375 | — | IC50 | = | 8650.0 | nM | 5.06 |
| CHEMBL244230 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL395281 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL397232 | — | IC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL241856 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL245080 | — | IC50 | = | 64500.0 | nM | 4.19 |
| CHEMBL395282 | — | IC50 | = | 65400.0 | nM | 4.18 |
| CHEMBL415423 | — | IC50 | = | 67900.0 | nM | 4.17 |
| CHEMBL395280 | HUPERZINE A | IC50 | = | 70200.0 | nM | 4.15 |
| CHEMBL440054 | — | IC50 | = | 88400.0 | nM | 4.05 |
| CHEMBL245081 | — | IC50 | - | — | - | |
| CHEMBL389583 | — | IC50 | = | 125000.0 | nM | - |
| CHEMBL438305 | — | IC50 | - | — | - | |
| CHEMBL242068 | — | IC50 | - | — | - | |
| CHEMBL263097 | — | IC50 | - | — | - | |
| CHEMBL397501 | — | IC50 | - | — | - | |
| CHEMBL395106 | — | IC50 | - | — | - | |
| CHEMBL395043 | — | IC50 | - | — | - | |
| CHEMBL395274 | — | IC50 | - | — | - | |
| CHEMBL389374 | — | IC50 | - | — | - | |
| CHEMBL395520 | — | IC50 | - | — | - | |
| CHEMBL245079 | HUPERZINE B | IC50 | = | 228000.0 | nM | - |
| CHEMBL244870 | — | IC50 | > | 184000.0 | nM | - |
| CHEMBL395283 | — | IC50 | = | 171000.0 | nM | - |
| CHEMBL389582 | — | IC50 | = | 192000.0 | nM | - |
| CHEMBL267591 | — | IC50 | - | — | - | |
| CHEMBL413241 | — | IC50 | - | — | - | |
| CHEMBL413242 | — | IC50 | - | — | - | |
| CHEMBL267836 | — | IC50 | - | — | - | |
| CHEMBL413243 | — | IC50 | - | — | - | |
| CHEMBL413244 | — | IC50 | - | — | - | |
| CHEMBL389580 | — | IC50 | - | — | - | |
| CHEMBL242755 | — | IC50 | - | — | - | |
| CHEMBL263098 | — | IC50 | - | — | - | |
| CHEMBL389779 | — | IC50 | - | — | - | |
| CHEMBL413170 | — | IC50 | - | — | - | |
| CHEMBL267606 | — | IC50 | - | — | - | |
| CHEMBL244027 | — | IC50 | - | — | - | |
| CHEMBL413018 | — | IC50 | - | — | - | |
| CHEMBL413240 | — | IC50 | - | — | - | |
| CHEMBL244026 | — | IC50 | - | — | - |