Assay Detail
Binding
CHEMBL891324
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Inhibition of ICE
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of unsaturated caprolactams as interleukin-1beta converting enzyme (ICE) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 8.06 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL411178 | — | — | 1 | 9.00 |
| CHEMBL268772 | — | — | 1 | 9.00 |
| CHEMBL394351 | — | — | 1 | 9.00 |
| CHEMBL243823 | — | — | 1 | 8.70 |
| CHEMBL397184 | — | — | 1 | 8.70 |
| CHEMBL411759 | — | — | 1 | 8.52 |
| CHEMBL242298 | — | — | 1 | 8.52 |
| CHEMBL437105 | VRT-18858 | -1.0 | 1 | 8.40 |
| CHEMBL396534 | — | — | 1 | 8.40 |
| CHEMBL411758 | — | — | 1 | 8.15 |
| CHEMBL244229 | — | — | 1 | 8.10 |
| CHEMBL397990 | — | — | 1 | 7.96 |
| CHEMBL242937 | — | — | 1 | 7.89 |
| CHEMBL242509 | — | — | 1 | 7.85 |
| CHEMBL242727 | — | — | 1 | 7.82 |
| CHEMBL242938 | — | — | 1 | 7.72 |
| CHEMBL242510 | — | — | 1 | 7.70 |
| CHEMBL442714 | — | — | 1 | 7.66 |
| CHEMBL396535 | — | — | 1 | 7.57 |
| CHEMBL242726 | — | — | 1 | 7.54 |
| CHEMBL429646 | — | — | 1 | 7.28 |
| CHEMBL242299 | — | — | 1 | 7.11 |
| CHEMBL242511 | — | — | 1 | 6.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL411178 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL268772 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL394351 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL243823 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL397184 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL411759 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL242298 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL437105 | VRT-18858 | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL396534 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL411758 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL244229 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL397990 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL242937 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL242509 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL242727 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL242938 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL242510 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL442714 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL396535 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL242726 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL429646 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL242299 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL242511 | — | IC50 | = | 168.0 | nM | 6.78 |