Assay Detail
Binding
CHEMBL891326
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Inhibition of caspase 8
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Synthesis and evaluation of unsaturated caprolactams as interleukin-1beta converting enzyme (ICE) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.95 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL411759 | — | — | 1 | 6.96 |
| CHEMBL394351 | — | — | 1 | 6.79 |
| CHEMBL411178 | — | — | 1 | 6.35 |
| CHEMBL268772 | — | — | 1 | 6.33 |
| CHEMBL242937 | — | — | 1 | 6.27 |
| CHEMBL242727 | — | — | 1 | 6.26 |
| CHEMBL243823 | — | — | 1 | 6.05 |
| CHEMBL397184 | — | — | 1 | 5.96 |
| CHEMBL242726 | — | — | 1 | 5.93 |
| CHEMBL429646 | — | — | 1 | 5.91 |
| CHEMBL242510 | — | — | 1 | 5.84 |
| CHEMBL244229 | — | — | 1 | 5.79 |
| CHEMBL397990 | — | — | 1 | 5.71 |
| CHEMBL442714 | — | — | 1 | 5.68 |
| CHEMBL242509 | — | — | 1 | 5.67 |
| CHEMBL242938 | — | — | 1 | 5.57 |
| CHEMBL396535 | — | — | 1 | 5.53 |
| CHEMBL242511 | — | — | 1 | 5.38 |
| CHEMBL411758 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL411759 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL394351 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL411178 | — | IC50 | = | 448.0 | nM | 6.35 |
| CHEMBL268772 | — | IC50 | = | 471.0 | nM | 6.33 |
| CHEMBL242937 | — | IC50 | = | 537.0 | nM | 6.27 |
| CHEMBL242727 | — | IC50 | = | 554.0 | nM | 6.26 |
| CHEMBL243823 | — | IC50 | = | 887.0 | nM | 6.05 |
| CHEMBL397184 | — | IC50 | = | 1085.0 | nM | 5.96 |
| CHEMBL242726 | — | IC50 | = | 1184.0 | nM | 5.93 |
| CHEMBL429646 | — | IC50 | = | 1231.0 | nM | 5.91 |
| CHEMBL242510 | — | IC50 | = | 1451.0 | nM | 5.84 |
| CHEMBL244229 | — | IC50 | = | 1606.0 | nM | 5.79 |
| CHEMBL397990 | — | IC50 | = | 1957.0 | nM | 5.71 |
| CHEMBL442714 | — | IC50 | = | 2110.0 | nM | 5.68 |
| CHEMBL242509 | — | IC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL242938 | — | IC50 | = | 2688.0 | nM | 5.57 |
| CHEMBL396535 | — | IC50 | = | 2935.0 | nM | 5.53 |
| CHEMBL242511 | — | IC50 | = | 4196.0 | nM | 5.38 |
| CHEMBL411758 | — | IC50 | = | 10000.0 | nM | 5.00 |