Assay Detail
Functional
CHEMBL891367
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at delta opioid receptor in mouse vas deferens assessed as inhibition of deltorphin 2-induced effect on muscle contractions
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Vas deferens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Transformation of mu-opioid receptor agonists into biologically potent mu-opioid receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 6.96 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL412923 | — | — | 1 | 8.60 |
| CHEMBL412924 | — | — | 1 | 7.32 |
| CHEMBL397177 | — | — | 1 | 7.15 |
| CHEMBL232303 | — | — | 1 | 6.83 |
| CHEMBL396506 | — | — | 1 | 6.38 |
| CHEMBL412922 | — | — | 1 | 6.32 |
| CHEMBL397176 | — | — | 1 | 6.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL412923 | — | Kd | = | 2.512 | nM | 8.60 |
| CHEMBL412924 | — | Kd | = | 47.86 | nM | 7.32 |
| CHEMBL397177 | — | Kd | = | 70.79 | nM | 7.15 |
| CHEMBL232303 | — | Kd | = | 147.91 | nM | 6.83 |
| CHEMBL396506 | — | Kd | = | 416.87 | nM | 6.38 |
| CHEMBL412922 | — | Kd | = | 478.63 | nM | 6.32 |
| CHEMBL397176 | — | Kd | = | 741.31 | nM | 6.13 |