Assay Detail
Functional
CHEMBL891424
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 RT 181C mutant assessed as inhibition of viral-induced cytopathicity in MT4 cells by MTT method
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Structure-activity relationship in the 3-iodo-4-phenoxypyridinone (IOPY) series: The nature of the C-3 substituent on anti-HIV activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.26 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.70 |
| CHEMBL233664 | — | — | 1 | 7.70 |
| CHEMBL234283 | — | — | 1 | 7.70 |
| CHEMBL233452 | — | — | 1 | 7.50 |
| CHEMBL397934 | — | — | 1 | 7.40 |
| CHEMBL395522 | — | — | 1 | 7.40 |
| CHEMBL233663 | — | — | 1 | 7.30 |
| CHEMBL234077 | — | — | 1 | 7.20 |
| CHEMBL234282 | — | — | 1 | 7.00 |
| CHEMBL233662 | — | — | 1 | 6.80 |
| CHEMBL233453 | — | — | 1 | 6.80 |
| CHEMBL234285 | — | — | 1 | 6.80 |
| CHEMBL234284 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | IC50 | = | 1.99 | nM | 8.70 |
| CHEMBL233664 | — | IC50 | = | 19.9 | nM | 7.70 |
| CHEMBL234283 | — | IC50 | = | 19.9 | nM | 7.70 |
| CHEMBL233452 | — | IC50 | = | 31.6 | nM | 7.50 |
| CHEMBL397934 | — | IC50 | = | 39.8 | nM | 7.40 |
| CHEMBL395522 | — | IC50 | = | 39.8 | nM | 7.40 |
| CHEMBL233663 | — | IC50 | = | 50.1 | nM | 7.30 |
| CHEMBL234077 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL234282 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL233662 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL233453 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL234285 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL234284 | — | IC50 | = | 794.0 | nM | 6.10 |