Assay Detail
Binding
CHEMBL891430
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Inhibition of human recombinant cathepsin K
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Acyclic, orally bioavailable ketone-based cathepsin K inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 8.04 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL232712 | — | — | 1 | 8.85 |
| CHEMBL232911 | — | — | 1 | 8.68 |
| CHEMBL232713 | — | — | 1 | 8.49 |
| CHEMBL393354 | — | — | 1 | 8.42 |
| CHEMBL203463 | — | — | 1 | 8.40 |
| CHEMBL232520 | — | — | 1 | 8.26 |
| CHEMBL233706 | — | — | 1 | 8.19 |
| CHEMBL31545 | — | — | 1 | 8.12 |
| CHEMBL393673 | — | — | 1 | 8.12 |
| CHEMBL540964 | — | — | 1 | 7.75 |
| CHEMBL232518 | — | — | 1 | 7.50 |
| CHEMBL234368 | — | — | 1 | 7.19 |
| CHEMBL234576 | — | — | 1 | 6.52 |
| CHEMBL394698 | — | — | 1 | - |
| CHEMBL234367 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL232712 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL232911 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL232713 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL393354 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL203463 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL232520 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL233706 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL31545 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL393673 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL540964 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL232518 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL234368 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL234576 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL394698 | — | IC50 | > | 250.0 | nM | - |
| CHEMBL234367 | — | IC50 | = | 0.072 | nM | - |