Assay Detail
Binding
CHEMBL891433
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Inhibition of human recombinant cathepsin S
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Acyclic, orally bioavailable ketone-based cathepsin K inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.75 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL232712 | — | — | 1 | 8.10 |
| CHEMBL232713 | — | — | 1 | 8.00 |
| CHEMBL233706 | — | — | 1 | 8.00 |
| CHEMBL393354 | — | — | 1 | 7.96 |
| CHEMBL232520 | — | — | 1 | 7.82 |
| CHEMBL232911 | — | — | 1 | 7.72 |
| CHEMBL31545 | — | — | 1 | 7.70 |
| CHEMBL393673 | — | — | 1 | 7.58 |
| CHEMBL203463 | — | — | 1 | 7.46 |
| CHEMBL540964 | — | — | 1 | 7.19 |
| CHEMBL234367 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL232712 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL232713 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL233706 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL393354 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL232520 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL232911 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL31545 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL393673 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL203463 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL540964 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL234367 | — | IC50 | = | 0.21 | nM | - |