Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL891574

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against RSV Long in HEp2 cells assessed as reduction of virus-induced cytopathic effect
44
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Respiratory syncytial virus
Cell Type HEp2
Confidence 1 — Organism
Curated By Intermediate

Target

Respiratory syncytial virus (CHEMBL612679)
Type ORGANISM
Organism Respiratory syncytial virus

Publication

Respiratory syncytial virus fusion inhibitors. Part 4: optimization for oral bioavailability.
Yu KL, Sin N, Civiello RL, Wang XA, Combrink KD, Gulgeze HB, Venables BL, Wright JJ, Dalterio RA, Zadjura L, Marino A, Dando S, D'Arienzo C, Kadow KF, Cianci CW, Li Z, Clarke J, Genovesi EV, Medina I, Lamb L, Colonno RJ, Yang Z, Krystal M, Meanwell NA.
Bioorg Med Chem Lett (2007) 17 : 895 -901
PubMed 17169560 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 44 7.68 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL233892 1 8.52
CHEMBL234027 2 8.52
CHEMBL389156 1 8.52
CHEMBL446708 1 8.40
CHEMBL243029 2 8.30
CHEMBL14710 1 8.30
CHEMBL389339 1 8.22
CHEMBL234900 1 8.22
CHEMBL233786 1 8.22
CHEMBL243877 1 8.15
CHEMBL243878 1 8.10
CHEMBL389338 1 8.10
CHEMBL398805 1 8.00
CHEMBL388039 2 8.00
CHEMBL243876 2 8.00
CHEMBL243032 1 7.96
CHEMBL232604 1 7.96
CHEMBL393307 1 7.96
CHEMBL390633 1 7.89
CHEMBL243027 1 7.87
CHEMBL395001 1 7.82
CHEMBL232979 1 7.82
CHEMBL243031 1 7.82
CHEMBL233893 1 7.80
CHEMBL232978 1 7.77
CHEMBL243030 1 7.68
CHEMBL243026 1 7.43
CHEMBL243875 1 7.37
CHEMBL234901 1 7.29
CHEMBL400026 1 7.19

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL234027 EC50 = 3.0 nM 8.52
CHEMBL234027 EC50 = 3.0 nM 8.52
CHEMBL233892 EC50 = 3.0 nM 8.52
CHEMBL389156 EC50 = 3.0 nM 8.52
CHEMBL446708 EC50 = 4.0 nM 8.40
CHEMBL14710 EC50 = 5.0 nM 8.30
CHEMBL243029 EC50 = 5.0 nM 8.30
CHEMBL233786 EC50 = 6.0 nM 8.22
CHEMBL389339 EC50 = 6.0 nM 8.22
CHEMBL234900 EC50 = 6.0 nM 8.22
CHEMBL243877 EC50 = 7.0 nM 8.15
CHEMBL389338 EC50 = 8.0 nM 8.10
CHEMBL243878 EC50 = 8.0 nM 8.10
CHEMBL243029 EC50 = 9.0 nM 8.05
CHEMBL398805 EC50 = 10.0 nM 8.00
CHEMBL388039 EC50 = 10.0 nM 8.00
CHEMBL243876 EC50 = 10.0 nM 8.00
CHEMBL243032 EC50 = 11.0 nM 7.96
CHEMBL393307 EC50 = 11.0 nM 7.96
CHEMBL232604 EC50 = 11.0 nM 7.96
CHEMBL390633 EC50 = 13.0 nM 7.89
CHEMBL243027 EC50 = 13.5 nM 7.87
CHEMBL232979 EC50 = 15.0 nM 7.82
CHEMBL243031 EC50 = 15.0 nM 7.82
CHEMBL395001 EC50 = 15.0 nM 7.82
CHEMBL233893 EC50 = 16.0 nM 7.80
CHEMBL232978 EC50 = 17.0 nM 7.77
CHEMBL243876 EC50 = 21.0 nM 7.68
CHEMBL243030 EC50 = 21.0 nM 7.68
CHEMBL388039 EC50 = 29.0 nM 7.54
CHEMBL243026 EC50 = 37.0 nM 7.43
CHEMBL243875 EC50 = 43.0 nM 7.37
CHEMBL234901 EC50 = 51.0 nM 7.29
CHEMBL400026 EC50 = 65.0 nM 7.19
CHEMBL2096887 EC50 = 75.0 nM 7.12
CHEMBL234849 EC50 = 89.0 nM 7.05
CHEMBL390034 EC50 = 119.0 nM 6.92
CHEMBL392781 EC50 = 202.0 nM 6.70
CHEMBL391529 EC50 = 206.0 nM 6.69
CHEMBL398581 EC50 = 237.0 nM 6.62
CHEMBL243028 EC50 = 306.0 nM 6.51
CHEMBL234195 EC50 = 622.0 nM 6.21
CHEMBL234002 EC50 = 5710.0 nM 5.24
CHEMBL234004 EC50 < 2.3 nM -