Assay Detail
Binding
CHEMBL891639
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Inhibition of human ERbeta by radioligand binding assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
ERbeta ligands. Part 5: synthesis and structure-activity relationships of a series of 4'-hydroxyphenyl-aryl-carbaldehyde oxime derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.92 | 8.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 8.44 |
| CHEMBL231811 | — | — | 1 | 8.40 |
| CHEMBL394357 | — | — | 1 | 8.40 |
| CHEMBL231810 | — | — | 1 | 8.40 |
| CHEMBL395308 | — | — | 1 | 8.30 |
| CHEMBL232023 | — | — | 1 | 8.09 |
| CHEMBL438516 | — | — | 1 | 8.05 |
| CHEMBL44 | GENISTEIN | 2.0 | 1 | 8.01 |
| CHEMBL231812 | — | — | 1 | 8.00 |
| CHEMBL388418 | — | — | 1 | 7.92 |
| CHEMBL232022 | — | — | 1 | 6.70 |
| CHEMBL394614 | — | — | 1 | 6.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL231811 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL394357 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL231810 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL395308 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL232023 | — | IC50 | = | 8.05 | nM | 8.09 |
| CHEMBL438516 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL44 | GENISTEIN | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL231812 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL388418 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL232022 | — | IC50 | = | 202.0 | nM | 6.70 |
| CHEMBL394614 | — | IC50 | = | 457.0 | nM | 6.34 |