Assay Detail
Binding
CHEMBL891646
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Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
1,5-Benzodioxepin derivatives as a novel class of muscarinic M3 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 8.12 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL234440 | — | — | 1 | 9.92 |
| CHEMBL394137 | — | — | 1 | 9.18 |
| CHEMBL234258 | — | — | 1 | 8.74 |
| CHEMBL391977 | — | — | 1 | 8.72 |
| CHEMBL234439 | — | — | 1 | 8.70 |
| CHEMBL394254 | — | — | 1 | 8.62 |
| CHEMBL392186 | — | — | 1 | 8.29 |
| CHEMBL435353 | — | — | 1 | 8.22 |
| CHEMBL234438 | — | — | 1 | 8.21 |
| CHEMBL233201 | — | — | 1 | 8.14 |
| CHEMBL1231 | OXYBUTYNIN | 4.0 | 1 | 8.09 |
| CHEMBL394255 | — | — | 1 | 8.06 |
| CHEMBL234257 | — | — | 1 | 7.92 |
| CHEMBL233202 | — | — | 1 | 7.92 |
| CHEMBL233200 | — | — | 1 | 7.39 |
| CHEMBL233198 | — | — | 1 | 7.36 |
| CHEMBL234253 | — | — | 1 | 7.32 |
| CHEMBL233199 | — | — | 1 | 7.31 |
| CHEMBL234254 | — | — | 1 | 7.31 |
| CHEMBL234252 | — | — | 1 | 7.05 |
| CHEMBL234260 | — | — | 1 | - |
| CHEMBL429620 | — | — | 1 | - |
| CHEMBL435158 | — | — | 1 | - |
| CHEMBL234255 | — | — | 1 | - |
| CHEMBL234256 | — | — | 1 | - |
| CHEMBL392045 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL234440 | — | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL394137 | — | Ki | = | 0.66 | nM | 9.18 |
| CHEMBL234258 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL391977 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL234439 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL394254 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL392186 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL435353 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL234438 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL233201 | — | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL1231 | OXYBUTYNIN | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL394255 | — | Ki | = | 8.8 | nM | 8.06 |
| CHEMBL234257 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL233202 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL233200 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL233198 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL234253 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL233199 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL234254 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL234252 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL234260 | — | Ki | - | — | - | |
| CHEMBL429620 | — | Ki | - | — | - | |
| CHEMBL435158 | — | Ki | - | — | - | |
| CHEMBL234255 | — | Ki | - | — | - | |
| CHEMBL234256 | — | Ki | - | — | - | |
| CHEMBL392045 | — | Ki | - | — | - |