Assay Detail
Binding
CHEMBL891691
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Inhibition of Escherichia coli FabH
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
3-oxoacyl-[acyl-carrier-protein] synthase 3 (CHEMBL1795135) ↗| Type | SINGLE PROTEIN |
| Organism | Escherichia coli |
Publication
Synthesis and biological evaluation of thiazolidine-2-one 1,1-dioxide as inhibitors of Escherichia coli beta-ketoacyl-ACP-synthase III (FabH).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.27 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL391599 | — | — | 1 | 6.05 |
| CHEMBL233867 | — | — | 1 | 5.96 |
| CHEMBL397859 | — | — | 1 | 5.72 |
| CHEMBL234754 | — | — | 1 | 5.62 |
| CHEMBL234545 | — | — | 1 | 4.96 |
| CHEMBL396081 | — | — | 1 | 4.86 |
| CHEMBL393088 | — | — | 1 | 4.84 |
| CHEMBL234753 | — | — | 1 | 4.75 |
| CHEMBL398054 | — | — | 1 | 4.68 |
| CHEMBL232480 | — | — | 1 | - |
| CHEMBL232479 | — | — | 1 | - |
| CHEMBL397860 | — | — | 1 | - |
| CHEMBL232277 | — | — | 1 | - |
| CHEMBL232276 | — | — | 1 | - |
| CHEMBL397404 | — | — | 1 | - |
| CHEMBL232274 | — | — | 1 | - |
| CHEMBL394409 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL391599 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL233867 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL397859 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL234754 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL234545 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL396081 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL393088 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL234753 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL398054 | — | IC50 | = | 20700.0 | nM | 4.68 |
| CHEMBL232480 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL232479 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL397860 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL232277 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL232276 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL397404 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL232274 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL394409 | — | IC50 | > | 100000.0 | nM | - |