Assay Detail
Functional
CHEMBL892080
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Cytotoxicity against human Taxol-adriamycin-resistant NCI cells after 72 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of novel analogues of dictyostatin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.62 | 8.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL395497 | — | — | 1 | 8.09 |
| CHEMBL226880 | DICTYOSTATIN | — | 1 | 8.01 |
| CHEMBL364447 | DISERMOLIDE | 2.0 | 1 | 6.80 |
| CHEMBL388892 | — | — | 1 | 6.00 |
| CHEMBL232215 | — | — | 1 | 5.96 |
| CHEMBL226932 | — | — | 1 | 5.82 |
| CHEMBL234271 | — | — | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL395497 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL226880 | DICTYOSTATIN | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL364447 | DISERMOLIDE | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL388892 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL232215 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL226932 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL234271 | — | IC50 | = | 2100.0 | nM | 5.68 |