Assay Detail
Functional
CHEMBL892220
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity at rat recombinant mGluR6 expressed in CHO cells assessed as cAMP production
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Metabotropic glutamate receptor 6 (CHEMBL3842) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and preliminary pharmacological evaluation of the four stereoisomers of (2S)-2-(2'-phosphono-3'-phenylcyclopropyl)glycine, the first class of 3'-substituted trans C1'-2'-2-(2'-phosphonocyclopropyl)glycines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.19 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL33567 | — | — | 1 | 6.47 |
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 5.12 |
| CHEMBL442076 | — | — | 1 | 4.89 |
| CHEMBL392420 | — | — | 1 | 4.29 |
| CHEMBL392419 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL33567 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL575060 | GLUTAMIC ACID | EC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL442076 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL392420 | — | EC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL392419 | — | EC50 | > | 1000000.0 | nM | - |