Assay Detail
Binding
CHEMBL892223
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]LY341495 from rat recombinant mGluR8 expressed in BHK cells by SPA assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | BHK |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Metabotropic glutamate receptor 8 (CHEMBL2718) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and preliminary pharmacological evaluation of the four stereoisomers of (2S)-2-(2'-phosphono-3'-phenylcyclopropyl)glycine, the first class of 3'-substituted trans C1'-2'-2-(2'-phosphonocyclopropyl)glycines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.13 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL33567 | — | — | 1 | 5.72 |
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 5.47 |
| CHEMBL442076 | — | — | 1 | 4.20 |
| CHEMBL392420 | — | — | 1 | - |
| CHEMBL396319 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL33567 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL575060 | GLUTAMIC ACID | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL442076 | — | Ki | = | 63000.0 | nM | 4.20 |
| CHEMBL392420 | — | Ki | = | 130000.0 | nM | - |
| CHEMBL396319 | — | Ki | = | 190000.0 | nM | - |