Assay Detail
Binding
CHEMBL892235
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Displacement of [3H]prazosin from adrenergic alpha-1 receptor in rat cortical membranes
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Naphthyl piperazines with dual activity as 5-HT1D antagonists and 5-HT reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.22 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL83617 | — | — | 1 | 9.15 |
| CHEMBL234447 | — | — | 1 | 7.80 |
| CHEMBL3706924 | — | — | 1 | 7.37 |
| CHEMBL3706923 | — | — | 1 | 7.19 |
| CHEMBL234448 | — | — | 1 | 7.13 |
| CHEMBL391271 | — | — | 1 | 7.10 |
| CHEMBL391272 | — | — | 1 | 7.04 |
| CHEMBL234449 | — | — | 1 | 7.02 |
| CHEMBL391273 | — | — | 1 | 6.75 |
| CHEMBL3706925 | — | — | 1 | 6.47 |
| CHEMBL233210 | — | — | 1 | 6.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL83617 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL234447 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL3706924 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL3706923 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL234448 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL391271 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL391272 | — | Ki | = | 91.0 | nM | 7.04 |
| CHEMBL234449 | — | Ki | = | 96.0 | nM | 7.02 |
| CHEMBL391273 | — | Ki | = | 178.0 | nM | 6.75 |
| CHEMBL3706925 | — | Ki | = | 338.0 | nM | 6.47 |
| CHEMBL233210 | — | Ki | = | 353.0 | nM | 6.45 |