Assay Detail
Binding
CHEMBL892378
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Binding affinity to muscarinic M2 receptor
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Quantitative structure-selectivity relationship for M2 selectivity between M1 and M2 of piperidinyl piperidine derivatives as muscarinic antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 9.25 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308566 | — | — | 1 | 9.96 |
| CHEMBL73893 | — | — | 1 | 9.80 |
| CHEMBL74117 | — | — | 1 | 9.59 |
| CHEMBL421113 | — | — | 1 | 9.54 |
| CHEMBL440491 | — | — | 1 | 9.52 |
| CHEMBL72408 | — | — | 1 | 9.46 |
| CHEMBL72494 | — | — | 1 | 9.44 |
| CHEMBL72551 | — | — | 1 | 9.42 |
| CHEMBL72363 | — | — | 1 | 9.42 |
| CHEMBL72957 | — | — | 1 | 9.39 |
| CHEMBL70860 | — | — | 1 | 9.35 |
| CHEMBL73245 | — | — | 1 | 9.34 |
| CHEMBL74352 | — | — | 1 | 9.23 |
| CHEMBL307234 | — | — | 1 | 9.00 |
| CHEMBL420008 | — | — | 1 | 8.94 |
| CHEMBL422770 | — | — | 1 | 8.84 |
| CHEMBL70848 | — | — | 1 | 8.66 |
| CHEMBL72787 | — | — | 1 | 8.52 |
| CHEMBL305607 | — | — | 1 | 8.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308566 | — | Ki | = | 0.1099 | nM | 9.96 |
| CHEMBL73893 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL74117 | — | Ki | = | 0.26 | nM | 9.59 |
| CHEMBL421113 | — | Ki | = | 0.2897 | nM | 9.54 |
| CHEMBL440491 | — | Ki | = | 0.2999 | nM | 9.52 |
| CHEMBL72408 | — | Ki | = | 0.3499 | nM | 9.46 |
| CHEMBL72494 | — | Ki | = | 0.3597 | nM | 9.44 |
| CHEMBL72551 | — | Ki | = | 0.3802 | nM | 9.42 |
| CHEMBL72363 | — | Ki | = | 0.3802 | nM | 9.42 |
| CHEMBL72957 | — | Ki | = | 0.4102 | nM | 9.39 |
| CHEMBL70860 | — | Ki | = | 0.4498 | nM | 9.35 |
| CHEMBL73245 | — | Ki | = | 0.4603 | nM | 9.34 |
| CHEMBL74352 | — | Ki | = | 0.5902 | nM | 9.23 |
| CHEMBL307234 | — | Ki | = | 0.9908 | nM | 9.00 |
| CHEMBL420008 | — | Ki | = | 1.14 | nM | 8.94 |
| CHEMBL422770 | — | Ki | = | 1.449 | nM | 8.84 |
| CHEMBL70848 | — | Ki | = | 2.198 | nM | 8.66 |
| CHEMBL72787 | — | Ki | = | 2.992 | nM | 8.52 |
| CHEMBL305607 | — | Ki | = | 3.802 | nM | 8.42 |