Assay Detail
Binding
CHEMBL892390
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FXR in HEK293 cells in presence of CDCA by GAL4 transactivation activity
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Design, synthesis, and evaluation of non-steroidal farnesoid X receptor (FXR) antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.95 | 5.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL234747 | — | — | 1 | 5.43 |
| CHEMBL234371 | — | — | 1 | 5.40 |
| CHEMBL410683 | GUGGULSTERONE | — | 1 | 4.92 |
| CHEMBL274652 | — | — | 1 | 4.80 |
| CHEMBL231899 | — | — | 1 | 4.65 |
| CHEMBL398012 | — | — | 1 | 4.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL234747 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL234371 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL410683 | GUGGULSTERONE | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL274652 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL231899 | — | IC50 | = | 22200.0 | nM | 4.65 |
| CHEMBL398012 | — | IC50 | = | 33900.0 | nM | 4.47 |