Assay Detail
Binding
CHEMBL892514
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Inhibition of human Abl kinase expressed in Sf9 cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Structural factors contributing to the Abl/Lyn dual inhibitory activity of 3-substituted benzamide derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.49 | 8.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL203343 | — | — | 1 | 8.29 |
| CHEMBL205723 | — | — | 1 | 8.06 |
| CHEMBL536073 | — | — | 1 | 7.92 |
| CHEMBL383010 | — | — | 1 | 7.92 |
| CHEMBL206834 | BAFETINIB | 2.0 | 1 | 7.58 |
| CHEMBL538337 | — | — | 1 | 7.50 |
| CHEMBL205409 | — | — | 1 | 6.92 |
| CHEMBL536983 | — | — | 1 | 6.85 |
| CHEMBL941 | IMATINIB | 4.0 | 1 | 6.33 |
| CHEMBL536753 | — | — | 1 | - |
| CHEMBL203071 | — | — | 1 | - |
| CHEMBL382605 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL203343 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL205723 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL536073 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL383010 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL206834 | BAFETINIB | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL538337 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL205409 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL536983 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL941 | IMATINIB | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL536753 | — | IC50 | - | — | - | |
| CHEMBL203071 | — | IC50 | - | — | - | |
| CHEMBL382605 | — | IC50 | - | — | - |