Assay Detail
Binding
CHEMBL892686
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Inhibition of rat inducible NOS activity
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Nitric oxide synthase, inducible (CHEMBL3051) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Novel 2-aminobenzothiazoles as selective neuronal nitric oxide synthase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.54 | 4.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL233655 | — | — | 1 | 4.72 |
| CHEMBL233652 | — | — | 1 | 4.60 |
| CHEMBL233653 | — | — | 1 | 4.58 |
| CHEMBL233857 | — | — | 1 | 4.44 |
| CHEMBL412797 | — | — | 1 | 4.36 |
| CHEMBL233654 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL233655 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL233652 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL233653 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL233857 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL412797 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL233654 | — | IC50 | - | — | - |