Assay Detail
Functional
CHEMBL892763
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Cytotoxicity against human Hep 3B cells by MTT microassay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Hep 3B2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthetic 2',5'-dimethoxychalcones as G(2)/M arrest-mediated apoptosis-inducing agents and inhibitors of nitric oxide production in rat macrophages.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.94 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 6.22 |
| CHEMBL242977 | — | — | 1 | 5.47 |
| CHEMBL242335 | — | — | 1 | 5.24 |
| CHEMBL242123 | — | — | 1 | 5.08 |
| CHEMBL396806 | — | — | 1 | 4.96 |
| CHEMBL242749 | — | — | 1 | 4.92 |
| CHEMBL242978 | — | — | 1 | 4.78 |
| CHEMBL243197 | — | — | 1 | 4.76 |
| CHEMBL242734 | — | — | 1 | 4.72 |
| CHEMBL397045 | — | — | 1 | 4.63 |
| CHEMBL242976 | — | — | 1 | 4.58 |
| CHEMBL243198 | — | — | 1 | 4.54 |
| CHEMBL243199 | — | — | 1 | 4.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185 | FLUOROURACIL | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL242977 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL242335 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL242123 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL396806 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL242749 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL242978 | — | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL243197 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL242734 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL397045 | — | IC50 | = | 23200.0 | nM | 4.63 |
| CHEMBL242976 | — | IC50 | = | 26500.0 | nM | 4.58 |
| CHEMBL243198 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL243199 | — | IC50 | = | 42600.0 | nM | 4.37 |