Assay Detail
Binding
CHEMBL892800
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Displacement of [3H]8-OH-DPAT from serotonin 5HT1A receptor in rat brain hippocampus
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Hippocampus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel class of arylpiperazines containing N-acylated amino acids: their synthesis, 5-HT1A, 5-HT2A receptor affinity, and in vivo pharmacological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 7.78 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL232246 | — | — | 1 | 8.52 |
| CHEMBL208905 | — | — | 1 | 8.40 |
| CHEMBL279841 | — | — | 1 | 8.19 |
| CHEMBL209007 | — | — | 1 | 8.05 |
| CHEMBL232449 | — | — | 1 | 7.89 |
| CHEMBL232036 | — | — | 1 | 7.84 |
| CHEMBL232035 | — | — | 1 | 7.72 |
| CHEMBL378298 | — | — | 1 | 7.72 |
| CHEMBL390037 | — | — | 1 | 7.68 |
| CHEMBL207493 | — | — | 1 | 7.64 |
| CHEMBL408589 | — | — | 1 | 7.58 |
| CHEMBL398209 | — | — | 1 | 7.55 |
| CHEMBL390659 | — | — | 1 | 7.51 |
| CHEMBL398181 | — | — | 1 | 7.50 |
| CHEMBL232247 | — | — | 1 | 7.43 |
| CHEMBL231825 | — | — | 1 | 7.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL232246 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL208905 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL279841 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL209007 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL232449 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL232036 | — | Ki | = | 14.5 | nM | 7.84 |
| CHEMBL232035 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL378298 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL390037 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL207493 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL408589 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL398209 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL390659 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL398181 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL232247 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL231825 | — | Ki | = | 47.0 | nM | 7.33 |