Assay Detail
Functional
CHEMBL893104
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel benzodifuran analogs as potent 5-HT2A receptor agonists with ocular hypotensive activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.69 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL397321 | — | — | 1 | 8.24 |
| CHEMBL391196 | — | — | 1 | 8.21 |
| CHEMBL134519 | — | — | 1 | 7.92 |
| CHEMBL234682 | — | — | 1 | 7.64 |
| CHEMBL232995 | — | — | 1 | 7.23 |
| CHEMBL234837 | — | — | 1 | 6.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL397321 | — | EC50 | = | 5.8 | nM | 8.24 |
| CHEMBL391196 | — | EC50 | = | 6.2 | nM | 8.21 |
| CHEMBL134519 | — | EC50 | = | 11.9 | nM | 7.92 |
| CHEMBL234682 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL232995 | — | EC50 | = | 59.0 | nM | 7.23 |
| CHEMBL234837 | — | EC50 | = | 130.0 | nM | 6.89 |