Assay Detail
Functional
CHEMBL893105
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Agonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HT
8
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | SR3T3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel benzodifuran analogs as potent 5-HT2A receptor agonists with ocular hypotensive activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.50 | 8.35 |
| Emax | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL232995 | — | — | 1 | 8.35 |
| CHEMBL397321 | — | — | 1 | 8.07 |
| CHEMBL234464 | — | — | 1 | 7.90 |
| CHEMBL134519 | — | — | 2 | 7.52 |
| CHEMBL391196 | — | — | 1 | 7.41 |
| CHEMBL234682 | — | — | 1 | 7.09 |
| CHEMBL234837 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL232995 | — | EC50 | = | 4.5 | nM | 8.35 |
| CHEMBL397321 | — | EC50 | = | 8.6 | nM | 8.07 |
| CHEMBL234464 | — | EC50 | = | 12.6 | nM | 7.90 |
| CHEMBL134519 | — | EC50 | = | 30.2 | nM | 7.52 |
| CHEMBL391196 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL234682 | — | EC50 | = | 82.0 | nM | 7.09 |
| CHEMBL234837 | — | EC50 | = | 689.0 | nM | 6.16 |
| CHEMBL134519 | — | Emax | = | 84.0 | % | - |