Assay Detail
Functional
CHEMBL893107
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reduction of intra ocular pressure in cynomolgus monkey at 300 ug
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Macaca fascicularis |
| Tissue | Eye |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel benzodifuran analogs as potent 5-HT2A receptor agonists with ocular hypotensive activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 3 | - | - |
| EC50 | 1 | 8.56 | 8.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL134519 | — | — | 1 | 8.56 |
| CHEMBL391196 | — | — | 1 | - |
| CHEMBL234682 | — | — | 1 | - |
| CHEMBL234464 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL134519 | — | EC50 | = | 2.72 | nM | 8.56 |
| CHEMBL391196 | — | Activity | = | 24.0 | % | - |
| CHEMBL234682 | — | Activity | = | 27.0 | % | - |
| CHEMBL234464 | — | Activity | = | 36.8 | % | - |