Assay Detail
Functional
CHEMBL893370
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Antileukotrienic activity in rat polymorphonuclear cells assessed as inhibition of LTB4 biosynthesis
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antileukotrienic N-arylethyl-2-arylacetamides in the treatment of ulcerative colitis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.12 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL93 | ZILEUTON | 4.0 | 1 | 8.00 |
| CHEMBL390870 | — | — | 1 | 5.02 |
| CHEMBL241945 | — | — | 1 | 5.00 |
| CHEMBL242574 | — | — | 1 | 4.96 |
| CHEMBL241946 | — | — | 1 | 4.96 |
| CHEMBL242157 | — | — | 1 | 4.82 |
| CHEMBL242369 | — | — | 1 | 4.80 |
| CHEMBL242366 | — | — | 1 | 4.70 |
| CHEMBL390458 | — | — | 1 | 4.50 |
| CHEMBL242365 | — | — | 1 | 4.40 |
| CHEMBL244274 | — | — | 1 | - |
| CHEMBL242158 | — | — | 1 | - |
| CHEMBL242367 | — | — | 1 | - |
| CHEMBL244478 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL93 | ZILEUTON | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL390870 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL241945 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL242574 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL241946 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL242157 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL242369 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL242366 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL390458 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL242365 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL244274 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL242158 | — | IC50 | - | — | - | |
| CHEMBL242367 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL244478 | — | IC50 | > | 100000.0 | nM | - |