Assay Detail
Binding
CHEMBL893460
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Inhibition of TC-PTP
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Tyrosine-protein phosphatase non-receptor type 2 (CHEMBL3807) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Methylenedisalicylic acid derivatives: new PTP1B inhibitors that confer resistance to diet-induced obesity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | - | - |
| Ki | 2 | 4.40 | 4.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3706920 | — | — | 2 | 4.60 |
| CHEMBL228397 | — | — | 2 | 4.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3706920 | — | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL228397 | — | Ki | = | 64000.0 | nM | 4.19 |
| CHEMBL228397 | — | IC50 | = | 291000.0 | nM | - |
| CHEMBL3706920 | — | IC50 | = | 146000.0 | nM | - |