Assay Detail
Binding
CHEMBL893545
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Inhibition of tetracycline-induced iNOS expressed in SF9 cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
1-(1,3-Benzodioxol-5-ylmethyl)-3-[4-(1H-imidazol-1-yl)phenoxy]-piperidine analogs as potent and selective inhibitors of nitric oxide formation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.41 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL232827 | — | — | 1 | 7.14 |
| CHEMBL233031 | — | — | 1 | 6.92 |
| CHEMBL232825 | — | — | 1 | 6.60 |
| CHEMBL233032 | — | — | 1 | 6.23 |
| CHEMBL388881 | — | — | 1 | 5.92 |
| CHEMBL233236 | — | — | 1 | 5.66 |
| CHEMBL233235 | — | — | 1 | - |
| CHEMBL388880 | — | — | 1 | - |
| CHEMBL233030 | — | — | 1 | - |
| CHEMBL388417 | — | — | 1 | - |
| CHEMBL388205 | — | — | 1 | - |
| CHEMBL232826 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL232827 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL233031 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL232825 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL233032 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL388881 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL233236 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL233235 | — | IC50 | - | — | - | |
| CHEMBL388880 | — | IC50 | - | — | - | |
| CHEMBL233030 | — | IC50 | - | — | - | |
| CHEMBL388417 | — | IC50 | - | — | - | |
| CHEMBL388205 | — | IC50 | - | — | - | |
| CHEMBL232826 | — | IC50 | - | — | - |