Assay Detail
Functional
CHEMBL893556
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Effect on pigment aggregation in Xenopus laevis melanophores
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Xenopus laevis |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
7-Substituted-melatonin and 7-substituted-1-methylmelatonin analogues: effect of substituents on potency and binding affinity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 7.70 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45 | MELATONIN | 4.0 | 1 | 10.10 |
| CHEMBL233728 | — | — | 1 | 8.48 |
| CHEMBL233308 | — | — | 1 | 8.46 |
| CHEMBL392421 | — | — | 1 | 8.01 |
| CHEMBL233729 | — | — | 1 | 7.94 |
| CHEMBL391350 | — | — | 1 | 7.90 |
| CHEMBL233516 | — | — | 1 | 7.80 |
| CHEMBL392422 | — | — | 1 | 7.78 |
| CHEMBL233309 | — | — | 1 | 7.61 |
| CHEMBL395221 | — | — | 1 | 7.50 |
| CHEMBL231872 | — | — | 1 | 7.34 |
| CHEMBL394408 | — | — | 1 | 7.34 |
| CHEMBL394406 | — | — | 1 | 7.28 |
| CHEMBL233310 | — | — | 1 | 7.19 |
| CHEMBL233311 | — | — | 1 | 6.92 |
| CHEMBL233517 | — | — | 1 | 6.81 |
| CHEMBL233740 | — | — | 1 | 6.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45 | MELATONIN | EC50 | = | 0.07943 | nM | 10.10 |
| CHEMBL233728 | — | EC50 | = | 3.311 | nM | 8.48 |
| CHEMBL233308 | — | EC50 | = | 3.467 | nM | 8.46 |
| CHEMBL392421 | — | EC50 | = | 9.772 | nM | 8.01 |
| CHEMBL233729 | — | EC50 | = | 11.48 | nM | 7.94 |
| CHEMBL391350 | — | EC50 | = | 12.59 | nM | 7.90 |
| CHEMBL233516 | — | EC50 | = | 15.85 | nM | 7.80 |
| CHEMBL392422 | — | EC50 | = | 16.6 | nM | 7.78 |
| CHEMBL233309 | — | EC50 | = | 24.55 | nM | 7.61 |
| CHEMBL395221 | — | EC50 | = | 31.62 | nM | 7.50 |
| CHEMBL231872 | — | EC50 | = | 45.71 | nM | 7.34 |
| CHEMBL394408 | — | EC50 | = | 45.71 | nM | 7.34 |
| CHEMBL394406 | — | EC50 | = | 52.48 | nM | 7.28 |
| CHEMBL233310 | — | EC50 | = | 64.57 | nM | 7.19 |
| CHEMBL233311 | — | EC50 | = | 120.23 | nM | 6.92 |
| CHEMBL233517 | — | EC50 | = | 154.88 | nM | 6.81 |
| CHEMBL233740 | — | EC50 | = | 338.84 | nM | 6.47 |