Assay Detail
Binding
CHEMBL893728
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Binding affinity to human survivin expressed in Escherichia coli BL21 cells after 30 mins
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BL21 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Baculoviral IAP repeat-containing protein 5 (CHEMBL5989) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a novel small molecule binding site of human survivin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 32 | 6.21 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL234358 | — | — | 1 | 7.43 |
| CHEMBL233848 | — | — | 1 | 7.32 |
| CHEMBL272921 | — | — | 1 | 7.22 |
| CHEMBL234330 | — | — | 1 | 7.19 |
| CHEMBL234040 | — | — | 1 | 7.12 |
| CHEMBL232404 | — | — | 1 | 7.07 |
| CHEMBL234421 | — | — | 1 | 7.00 |
| CHEMBL234041 | — | — | 1 | 6.70 |
| CHEMBL396856 | — | — | 1 | 6.66 |
| CHEMBL394046 | — | — | 1 | 6.58 |
| CHEMBL428195 | — | — | 1 | 6.36 |
| CHEMBL236619 | — | — | 1 | 6.31 |
| CHEMBL232402 | — | — | 1 | 6.29 |
| CHEMBL236620 | — | — | 1 | 6.28 |
| CHEMBL392286 | — | — | 1 | 6.28 |
| CHEMBL392285 | — | — | 1 | 6.21 |
| CHEMBL391106 | — | — | 1 | 6.16 |
| CHEMBL391681 | — | — | 1 | 6.16 |
| CHEMBL393124 | — | — | 1 | 6.09 |
| CHEMBL234608 | — | — | 1 | 6.06 |
| CHEMBL236829 | — | — | 1 | 5.93 |
| CHEMBL234852 | — | — | 1 | 5.53 |
| CHEMBL391586 | — | — | 1 | 5.30 |
| CHEMBL233218 | — | — | 1 | 5.30 |
| CHEMBL399196 | — | — | 1 | 5.12 |
| CHEMBL232201 | BENZIODARONE | 4.0 | 1 | 5.10 |
| CHEMBL397092 | — | — | 1 | 5.00 |
| CHEMBL441913 | — | — | 1 | 4.12 |
| CHEMBL277554 | — | — | 1 | - |
| CHEMBL232200 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL234358 | — | Kd | = | 37.0 | nM | 7.43 |
| CHEMBL233848 | — | Kd | = | 48.0 | nM | 7.32 |
| CHEMBL272921 | — | Kd | = | 60.0 | nM | 7.22 |
| CHEMBL234330 | — | Kd | = | 64.0 | nM | 7.19 |
| CHEMBL234040 | — | Kd | = | 76.0 | nM | 7.12 |
| CHEMBL232404 | — | Kd | = | 86.0 | nM | 7.07 |
| CHEMBL234421 | — | Kd | = | 100.0 | nM | 7.00 |
| CHEMBL234041 | — | Kd | = | 200.0 | nM | 6.70 |
| CHEMBL396856 | — | Kd | = | 220.0 | nM | 6.66 |
| CHEMBL394046 | — | Kd | = | 260.0 | nM | 6.58 |
| CHEMBL428195 | — | Kd | = | 440.0 | nM | 6.36 |
| CHEMBL236619 | — | Kd | = | 490.0 | nM | 6.31 |
| CHEMBL232402 | — | Kd | = | 510.0 | nM | 6.29 |
| CHEMBL236620 | — | Kd | = | 520.0 | nM | 6.28 |
| CHEMBL392286 | — | Kd | = | 530.0 | nM | 6.28 |
| CHEMBL392285 | — | Kd | = | 620.0 | nM | 6.21 |
| CHEMBL391106 | — | Kd | = | 700.0 | nM | 6.16 |
| CHEMBL391681 | — | Kd | = | 700.0 | nM | 6.16 |
| CHEMBL393124 | — | Kd | = | 810.0 | nM | 6.09 |
| CHEMBL234608 | — | Kd | = | 880.0 | nM | 6.06 |
| CHEMBL236829 | — | Kd | = | 1170.0 | nM | 5.93 |
| CHEMBL234852 | — | Kd | = | 2980.0 | nM | 5.53 |
| CHEMBL391586 | — | Kd | = | 5000.0 | nM | 5.30 |
| CHEMBL233218 | — | Kd | = | 5000.0 | nM | 5.30 |
| CHEMBL399196 | — | Kd | = | 7560.0 | nM | 5.12 |
| CHEMBL232201 | BENZIODARONE | Kd | = | 8000.0 | nM | 5.10 |
| CHEMBL397092 | — | Kd | = | 10000.0 | nM | 5.00 |
| CHEMBL441913 | — | Kd | = | 75000.0 | nM | 4.12 |
| CHEMBL277554 | — | Kd | = | 130000.0 | nM | - |
| CHEMBL232200 | — | Kd | < | 10000.0 | nM | - |
| CHEMBL395633 | — | Kd | < | 10000.0 | nM | - |
| CHEMBL392065 | — | Kd | > | 4300.0 | nM | - |