Assay Detail
Binding
CHEMBL893760
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DAGO from mu opioid receptor in rat brain membrane
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Differential receptor binding characteristics of consecutive phenylalanines in micro-opioid specific peptide ligand endomorphin-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.99 | 8.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38874 | DAMGO | — | 1 | 8.95 |
| CHEMBL316446 | ENDOMORPHIN-1 | — | 1 | 8.72 |
| CHEMBL242980 | — | — | 1 | 8.56 |
| CHEMBL333357 | ENDOMORPHIN 2 | — | 1 | 8.46 |
| CHEMBL397448 | — | — | 1 | 7.93 |
| CHEMBL243200 | — | — | 1 | 7.47 |
| CHEMBL242981 | — | — | 1 | 7.21 |
| CHEMBL242984 | — | — | 1 | 7.21 |
| CHEMBL390914 | — | — | 1 | 7.12 |
| CHEMBL388265 | — | — | 1 | 7.07 |
| CHEMBL364703 | — | — | 1 | 7.06 |
| CHEMBL243201 | — | — | 1 | 6.86 |
| CHEMBL223552 | — | — | 1 | 6.83 |
| CHEMBL438833 | — | — | 1 | 6.64 |
| CHEMBL1161991 | — | — | 1 | 6.39 |
| CHEMBL242979 | — | — | 1 | 6.04 |
| CHEMBL242089 | — | — | 1 | 6.03 |
| CHEMBL242974 | — | — | 1 | 5.96 |
| CHEMBL242087 | — | — | 1 | 5.58 |
| CHEMBL387816 | — | — | 1 | 5.42 |
| CHEMBL242330 | — | — | 1 | 5.35 |
| CHEMBL1161990 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38874 | DAMGO | IC50 | = | 1.13 | nM | 8.95 |
| CHEMBL316446 | ENDOMORPHIN-1 | IC50 | = | 1.89 | nM | 8.72 |
| CHEMBL242980 | — | IC50 | = | 2.74 | nM | 8.56 |
| CHEMBL333357 | ENDOMORPHIN 2 | IC50 | = | 3.46 | nM | 8.46 |
| CHEMBL397448 | — | IC50 | = | 11.7 | nM | 7.93 |
| CHEMBL243200 | — | IC50 | = | 33.9 | nM | 7.47 |
| CHEMBL242981 | — | IC50 | = | 62.2 | nM | 7.21 |
| CHEMBL242984 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL390914 | — | IC50 | = | 76.5 | nM | 7.12 |
| CHEMBL388265 | — | IC50 | = | 85.4 | nM | 7.07 |
| CHEMBL364703 | — | IC50 | = | 87.1 | nM | 7.06 |
| CHEMBL243201 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL223552 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL438833 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1161991 | — | IC50 | = | 408.0 | nM | 6.39 |
| CHEMBL242979 | — | IC50 | = | 917.0 | nM | 6.04 |
| CHEMBL242089 | — | IC50 | = | 926.0 | nM | 6.03 |
| CHEMBL242974 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL242087 | — | IC50 | = | 2650.0 | nM | 5.58 |
| CHEMBL387816 | — | IC50 | = | 3810.0 | nM | 5.42 |
| CHEMBL242330 | — | IC50 | = | 4490.0 | nM | 5.35 |
| CHEMBL1161990 | — | IC50 | > | 1000000.0 | nM | - |