Assay Detail
Binding
CHEMBL893770
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]N-methylscopolamine from human recombinant M3 muscarinic receptor expressed in CHO cell membrane
19
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Dual M3 antagonists-PDE4 inhibitors. Part 2: Synthesis and SAR of 3-substituted azetidinyl derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 7.32 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL234099 | — | — | 1 | 8.89 |
| CHEMBL205654 | — | — | 2 | 8.50 |
| CHEMBL389992 | — | — | 1 | 7.89 |
| CHEMBL232419 | — | — | 2 | 7.80 |
| CHEMBL232860 | — | — | 1 | 7.70 |
| CHEMBL434388 | — | — | 1 | 7.50 |
| CHEMBL232208 | — | — | 1 | 7.40 |
| CHEMBL395571 | — | — | 1 | 7.40 |
| CHEMBL232416 | — | — | 1 | 7.10 |
| CHEMBL434765 | — | — | 1 | 7.10 |
| CHEMBL396761 | — | — | 2 | 6.80 |
| CHEMBL242822 | — | — | 1 | 6.80 |
| CHEMBL242823 | — | — | 1 | 6.70 |
| CHEMBL232417 | — | — | 1 | 6.30 |
| CHEMBL436814 | — | — | 1 | 6.20 |
| CHEMBL245137 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL234099 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL205654 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL205654 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL389992 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL232419 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL232419 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL232860 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL434388 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL395571 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL232208 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL232416 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL434765 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL242822 | — | Ki | = | 158.0 | nM | 6.80 |
| CHEMBL396761 | — | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL242823 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL396761 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL232417 | — | Ki | = | 501.0 | nM | 6.30 |
| CHEMBL436814 | — | Ki | = | 631.0 | nM | 6.20 |
| CHEMBL245137 | — | Ki | = | 794.0 | nM | 6.10 |