Assay Detail
Binding
CHEMBL893890
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Helicobacter pylori ATCC 43504 urease in presence of 0.4 mM 2-mercaptoethanol after 3 hrs pre-incubation
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Helicobacter pylori |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Urease subunit alpha/Urease subunit beta (CHEMBL3885651) ↗| Type | PROTEIN COMPLEX |
| Organism | Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) |
Publication
Polyphenols based on isoflavones as inhibitors of Helicobacter pylori urease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.44 | 4.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL734 | ACETOHYDROXAMIC ACID | 4.0 | 1 | 4.72 |
| CHEMBL243822 | — | — | 1 | 4.15 |
| CHEMBL242739 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL734 | ACETOHYDROXAMIC ACID | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL243822 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL242739 | — | IC50 | > | 1480000.0 | nM | - |