Assay Detail
Binding
CHEMBL893891
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Helicobacter pylori ATCC 43504 urease in presence of 0.4 mM dithiothreitol after 3 hrs pre-incubation
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Helicobacter pylori |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Urease subunit alpha/Urease subunit beta (CHEMBL3885651) ↗| Type | PROTEIN COMPLEX |
| Organism | Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) |
Publication
Polyphenols based on isoflavones as inhibitors of Helicobacter pylori urease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.52 | 4.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL734 | ACETOHYDROXAMIC ACID | 4.0 | 1 | 4.75 |
| CHEMBL243822 | — | — | 1 | 4.28 |
| CHEMBL242739 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL734 | ACETOHYDROXAMIC ACID | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL243822 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL242739 | — | IC50 | > | 1480000.0 | nM | - |