Assay Detail
Functional
CHEMBL893910
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Cytotoxicity against human A375 cells after 24 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antiproliferative activity of some novel derivatives of diospyrin, a plant-derived naphthoquinonoid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.63 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 8.00 |
| CHEMBL396976 | — | — | 1 | 7.52 |
| CHEMBL396733 | — | — | 1 | 7.16 |
| CHEMBL244007 | — | — | 1 | 6.72 |
| CHEMBL242992 | — | — | 1 | 6.70 |
| CHEMBL242550 | DIOSPYRIN | — | 1 | 6.09 |
| CHEMBL244006 | — | — | 1 | 6.02 |
| CHEMBL243205 | — | — | 1 | 5.97 |
| CHEMBL243206 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL396976 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL396733 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL244007 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL242992 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL242550 | DIOSPYRIN | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL244006 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL243205 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL243206 | — | IC50 | = | 3180.0 | nM | 5.50 |