Assay Detail
ADMET
CHEMBL894025
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Growth inhibition of HUVEC cells by XTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Cell Type | HUVEC |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.11 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL424278 | O-CHLOROACETYLCARBAMOYLFUMAGILLOL | 2.0 | 1 | 9.70 |
| CHEMBL444369 | — | — | 1 | 7.52 |
| CHEMBL230005 | — | — | 1 | 7.40 |
| CHEMBL230641 | — | — | 1 | 6.82 |
| CHEMBL243305 | — | — | 1 | 5.70 |
| CHEMBL243303 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL424278 | O-CHLOROACETYLCARBAMOYLFUMAGILLOL | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL444369 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL230005 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL230641 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL243305 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL243303 | — | IC50 | = | 3000.0 | nM | 5.52 |