Assay Detail
Binding
CHEMBL894026
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Inhibition of human recombinant Mn2+-MetAP2
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.07 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL243303 | — | — | 1 | 6.75 |
| CHEMBL243305 | — | — | 1 | 6.20 |
| CHEMBL444369 | — | — | 1 | 5.82 |
| CHEMBL230641 | — | — | 1 | 5.82 |
| CHEMBL230005 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL243303 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL243305 | — | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL444369 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL230641 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL230005 | — | Ki | = | 1800.0 | nM | 5.75 |