Assay Detail
Binding
CHEMBL894057
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Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 7.17 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL243954 | — | — | 1 | 9.89 |
| CHEMBL18840 | — | — | 1 | 9.30 |
| CHEMBL243955 | — | — | 1 | 9.05 |
| CHEMBL243744 | — | — | 1 | 8.96 |
| CHEMBL243523 | — | — | 1 | 8.15 |
| CHEMBL244161 | — | — | 1 | 7.59 |
| CHEMBL243742 | — | — | 1 | 7.30 |
| CHEMBL244577 | — | — | 1 | 6.88 |
| CHEMBL390213 | — | — | 1 | 6.56 |
| CHEMBL389110 | — | — | 1 | 6.47 |
| CHEMBL243953 | — | — | 1 | 6.27 |
| CHEMBL243743 | — | — | 1 | 5.55 |
| CHEMBL390015 | — | — | 1 | 5.37 |
| CHEMBL244792 | — | — | 1 | 5.09 |
| CHEMBL244162 | — | — | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL243954 | — | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL18840 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL243955 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL243744 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL243523 | — | Ki | = | 7.1 | nM | 8.15 |
| CHEMBL244161 | — | Ki | = | 25.4 | nM | 7.59 |
| CHEMBL243742 | — | Ki | = | 49.6 | nM | 7.30 |
| CHEMBL244577 | — | Ki | = | 131.0 | nM | 6.88 |
| CHEMBL390213 | — | Ki | = | 278.0 | nM | 6.56 |
| CHEMBL389110 | — | Ki | = | 338.0 | nM | 6.47 |
| CHEMBL243953 | — | Ki | = | 538.0 | nM | 6.27 |
| CHEMBL243743 | — | Ki | = | 2810.0 | nM | 5.55 |
| CHEMBL390015 | — | Ki | = | 4253.0 | nM | 5.37 |
| CHEMBL244792 | — | Ki | = | 8027.0 | nM | 5.09 |
| CHEMBL244162 | — | Ki | = | 8178.0 | nM | 5.09 |