Assay Detail
Binding
CHEMBL894058
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in HEK293 cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 6.94 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56 | 8-OH-DPAT | — | 1 | 8.68 |
| CHEMBL244577 | — | — | 1 | 7.54 |
| CHEMBL390213 | — | — | 1 | 7.44 |
| CHEMBL243743 | — | — | 1 | 7.22 |
| CHEMBL243954 | — | — | 1 | 7.21 |
| CHEMBL243523 | — | — | 1 | 7.10 |
| CHEMBL243955 | — | — | 1 | 6.95 |
| CHEMBL244161 | — | — | 1 | 6.88 |
| CHEMBL243744 | — | — | 1 | 6.78 |
| CHEMBL243742 | — | — | 1 | 6.78 |
| CHEMBL244792 | — | — | 1 | 6.71 |
| CHEMBL244162 | — | — | 1 | 6.38 |
| CHEMBL243953 | — | — | 1 | 5.92 |
| CHEMBL389110 | — | — | 1 | 5.60 |
| CHEMBL390015 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56 | 8-OH-DPAT | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL244577 | — | Ki | = | 29.2 | nM | 7.54 |
| CHEMBL390213 | — | Ki | = | 36.4 | nM | 7.44 |
| CHEMBL243743 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL243954 | — | Ki | = | 60.9 | nM | 7.21 |
| CHEMBL243523 | — | Ki | = | 79.2 | nM | 7.10 |
| CHEMBL243955 | — | Ki | = | 112.0 | nM | 6.95 |
| CHEMBL244161 | — | Ki | = | 133.0 | nM | 6.88 |
| CHEMBL243744 | — | Ki | = | 167.0 | nM | 6.78 |
| CHEMBL243742 | — | Ki | = | 168.0 | nM | 6.78 |
| CHEMBL244792 | — | Ki | = | 194.0 | nM | 6.71 |
| CHEMBL244162 | — | Ki | = | 415.0 | nM | 6.38 |
| CHEMBL243953 | — | Ki | = | 1196.0 | nM | 5.92 |
| CHEMBL389110 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL390015 | — | Ki | - | — | - |