Assay Detail
Functional
CHEMBL894061
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction
15
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| %max | 8 | - | - |
| EC50 | 7 | 5.54 | 6.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18840 | — | — | 2 | 6.20 |
| CHEMBL243744 | — | — | 2 | 6.05 |
| CHEMBL243955 | — | — | 2 | 5.93 |
| CHEMBL243954 | — | — | 2 | 5.75 |
| CHEMBL222188 | — | — | 2 | 5.10 |
| CHEMBL225571 | — | — | 2 | 5.00 |
| CHEMBL222477 | — | — | 2 | 4.77 |
| CHEMBL244161 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18840 | — | EC50 | = | 630.0 | nM | 6.20 |
| CHEMBL243744 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL243955 | — | EC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL243954 | — | EC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL222188 | — | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL225571 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL222477 | — | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL18840 | — | %max | = | 100.0 | % | - |
| CHEMBL244161 | — | %max | = | - | % | - |
| CHEMBL243955 | — | %max | = | 100.0 | % | - |
| CHEMBL243954 | — | %max | = | 74.0 | % | - |
| CHEMBL243744 | — | %max | = | 83.0 | % | - |
| CHEMBL222477 | — | %max | = | 13.0 | % | - |
| CHEMBL225571 | — | %max | = | 24.0 | % | - |
| CHEMBL222188 | — | %max | = | 40.0 | % | - |