Assay Detail
Binding
CHEMBL894085
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Inhibition of human recombinant AChE
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.19 | 7.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL396199 | — | — | 1 | 7.98 |
| CHEMBL244416 | — | — | 1 | 7.74 |
| CHEMBL75121 | — | — | 1 | 7.35 |
| CHEMBL396247 | — | — | 1 | 7.31 |
| CHEMBL389825 | — | — | 1 | 7.21 |
| CHEMBL427865 | — | — | 1 | 6.91 |
| CHEMBL244619 | — | — | 1 | 6.83 |
| CHEMBL243532 | — | — | 1 | 6.79 |
| CHEMBL243310 | — | — | 1 | 6.70 |
| CHEMBL244624 | — | — | 1 | 6.55 |
| CHEMBL413794 | — | — | 1 | 6.52 |
| CHEMBL245046 | — | — | 1 | 6.51 |
| CHEMBL243130 | — | — | 1 | 6.44 |
| CHEMBL242905 | — | — | 1 | 6.43 |
| CHEMBL245047 | — | — | 1 | 6.15 |
| CHEMBL413793 | — | — | 1 | 6.05 |
| CHEMBL265416 | — | — | 1 | 6.01 |
| CHEMBL244838 | — | — | 1 | 5.91 |
| CHEMBL388714 | — | — | 1 | 5.80 |
| CHEMBL245054 | — | — | 1 | 5.70 |
| CHEMBL244415 | — | — | 1 | 5.65 |
| CHEMBL245055 | — | — | 1 | 5.64 |
| CHEMBL243311 | — | — | 1 | 5.64 |
| CHEMBL241827 | — | — | 1 | 5.51 |
| CHEMBL241828 | — | — | 1 | 4.74 |
| CHEMBL242906 | — | — | 1 | 4.61 |
| CHEMBL244837 | — | — | 1 | 4.52 |
| CHEMBL241830 | — | — | 1 | 4.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL396199 | — | IC50 | = | 10.5 | nM | 7.98 |
| CHEMBL244416 | — | IC50 | = | 18.3 | nM | 7.74 |
| CHEMBL75121 | — | IC50 | = | 44.5 | nM | 7.35 |
| CHEMBL396247 | — | IC50 | = | 49.3 | nM | 7.31 |
| CHEMBL389825 | — | IC50 | = | 62.1 | nM | 7.21 |
| CHEMBL427865 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL244619 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL243532 | — | IC50 | = | 163.0 | nM | 6.79 |
| CHEMBL243310 | — | IC50 | = | 202.0 | nM | 6.70 |
| CHEMBL244624 | — | IC50 | = | 281.0 | nM | 6.55 |
| CHEMBL413794 | — | IC50 | = | 303.0 | nM | 6.52 |
| CHEMBL245046 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL243130 | — | IC50 | = | 366.0 | nM | 6.44 |
| CHEMBL242905 | — | IC50 | = | 368.0 | nM | 6.43 |
| CHEMBL245047 | — | IC50 | = | 714.0 | nM | 6.15 |
| CHEMBL413793 | — | IC50 | = | 892.0 | nM | 6.05 |
| CHEMBL265416 | — | IC50 | = | 987.0 | nM | 6.01 |
| CHEMBL244838 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL388714 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL245054 | — | IC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL244415 | — | IC50 | = | 2260.0 | nM | 5.65 |
| CHEMBL245055 | — | IC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL243311 | — | IC50 | = | 2290.0 | nM | 5.64 |
| CHEMBL241827 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL241828 | — | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL242906 | — | IC50 | = | 24600.0 | nM | 4.61 |
| CHEMBL244837 | — | IC50 | = | 30300.0 | nM | 4.52 |
| CHEMBL241830 | — | IC50 | = | 80500.0 | nM | 4.09 |