Assay Detail
Functional
CHEMBL894090
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human GABAC rho 1 receptor expressed in HEK293 cells by FMP assay
26
Total Activities
17
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
5-Substituted imidazole-4-acetic acid analogues: synthesis, modeling, and pharmacological characterization of a series of novel gamma-aminobutyric acid(C) receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 24 | 5.13 | 6.26 |
| Ki | 2 | 5.89 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96 | GAMMA-AMINOBUTYRIC ACID | 1.0 | 2 | 6.26 |
| CHEMBL397209 | — | — | 2 | 5.89 |
| CHEMBL273481 | MUSCIMOL | 1.0 | 2 | 5.66 |
| CHEMBL784 | IMIDAZOLE ACETIC ACID | — | 2 | 4.89 |
| CHEMBL243929 | — | — | 2 | 4.66 |
| CHEMBL39071 | ISOGUVACINE | — | 2 | 4.17 |
| CHEMBL389759 | — | — | 1 | - |
| CHEMBL390208 | — | — | 1 | - |
| CHEMBL243723 | — | — | 1 | - |
| CHEMBL244137 | — | — | 1 | - |
| CHEMBL390207 | — | — | 1 | - |
| CHEMBL390012 | — | — | 2 | - |
| CHEMBL388249 | — | — | 2 | - |
| CHEMBL244136 | — | — | 1 | - |
| CHEMBL388248 | — | — | 1 | - |
| CHEMBL243932 | — | — | 2 | - |
| CHEMBL243281 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96 | GAMMA-AMINOBUTYRIC ACID | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL397209 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL273481 | MUSCIMOL | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL784 | IMIDAZOLE ACETIC ACID | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL243929 | — | EC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL39071 | ISOGUVACINE | EC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL96 | GAMMA-AMINOBUTYRIC ACID | EC50 | = | 1995262314968882.8 | nM | - |
| CHEMBL39071 | ISOGUVACINE | EC50 | = | 15848931924611.11 | nM | - |
| CHEMBL273481 | MUSCIMOL | EC50 | = | 501187233627271.44 | nM | - |
| CHEMBL397209 | — | Ki | = | 794328234724282.1 | nM | - |
| CHEMBL784 | IMIDAZOLE ACETIC ACID | EC50 | = | 79432823472428.22 | nM | - |
| CHEMBL243929 | — | EC50 | = | 39810717055349.7 | nM | - |
| CHEMBL389759 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL243723 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL244137 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL390207 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL390012 | — | EC50 | = | 210000.0 | nM | - |
| CHEMBL388249 | — | EC50 | = | 240000.0 | nM | - |
| CHEMBL244136 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL388248 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL243932 | — | EC50 | = | 420000.0 | nM | - |
| CHEMBL243932 | — | EC50 | = | 2511886431509.58 | nM | - |
| CHEMBL388249 | — | EC50 | = | 3981071705534.97 | nM | - |
| CHEMBL390012 | — | EC50 | = | 5011872336272.71 | nM | - |
| CHEMBL243281 | — | EC50 | - | — | - | |
| CHEMBL390208 | — | EC50 | > | 1000000.0 | nM | - |