Compound Detail
CHEMBL784
IMIDAZOLE ACETIC ACID Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL784 |
| Name | IMIDAZOLE ACETIC ACID |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PRJKNHOMHKJCEJ-UHFFFAOYSA-N |
8
Targets
36
Activities
3
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
126.1
MW (Da)
0.04
ALogP
2
HBA
2
HBD
66.0
PSA (Ų)
0.59
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 29 meas. best 5.76
IC50 5 meas. best 6.05
Ki 2 meas. best 6.2
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | Ki | 6.2 | 6.195 | 631.0 | 2 |
| GABA-A receptor; anion channel CHEMBL1907607 | IC50 | 6.05 | 6.05 | 900.0 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-2 CHEMBL4523641 | EC50 | 5.76 | 5.755 | 1737.8 | 2 |
| Gamma-aminobutyric acid receptor subunit rho-2 CHEMBL2375 | EC50 | 5.52 | 5.52 | 3000.0 | 1 |
| Gamma-aminobutyric acid receptor subunit rho-1 CHEMBL3561 | EC50 | 5.34 | 5.16 | 4570.9 | 3 |
| Unchecked CHEMBL612545 | EC50 | 5.3 | 4.955 | 5011.9 | 10 |
| GABA transporter 4 CHEMBL3699 | IC50 | 4.76 | 4.76 | 17378.0 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4/beta-2/gamma-2 CHEMBL4523640 | EC50 | 4.73 | 4.725 | 18620.9 | 2 |
| GABA-A receptor; alpha-1/beta-2/gamma-2 CHEMBL2095172 | EC50 | 4.62 | 4.615 | 24000.0 | 2 |
| Unchecked CHEMBL612545 | IC50 | 4.33 | 4.33 | 46773.5 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17655213 | 10.1021/jm070447j | Unchecked | 16 |
| 31117514 | 10.1021/acs.jmedchem.9b00026 | Gamma-aminobutyric acid receptor subunit rho-1 | 4 |
| 21353350 | 10.1016/j.ejmech.2011.01.042 | Unchecked | 4 |
| 31117514 | 10.1021/acs.jmedchem.9b00026 | Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-2 | 3 |
| 31117514 | 10.1021/acs.jmedchem.9b00026 | Gamma-aminobutyric acid receptor subunit alpha-4/beta-2/gamma-2 | 3 |
| 31117514 | 10.1021/acs.jmedchem.9b00026 | Unchecked | 3 |
| 31117514 | 10.1021/acs.jmedchem.9b00026 | GABA-A receptor; alpha-1/beta-2/gamma-2 | 3 |
| 17655213 | 10.1021/jm070447j | GABA A receptor alpha-1/beta-1/gamma-2 | 3 |
| 11412984 | 10.1016/s0960-894x(01)00184-6 | GABA-A receptor; alpha-6/beta-3/gamma-2 | 2 |
| 11412984 | 10.1016/s0960-894x(01)00184-6 | GABA-A receptor; alpha-5/beta-3/gamma-2 | 2 |
| 11412984 | 10.1016/s0960-894x(01)00184-6 | GABA A receptor alpha-4/beta-3/gamma-2 | 2 |
| 11412984 | 10.1016/s0960-894x(01)00184-6 | GABA-A receptor; alpha-3/beta-3/gamma-2 | 2 |
| 11412984 | 10.1016/s0960-894x(01)00184-6 | GABA-A receptor; alpha-2/beta-3/gamma-2 | 2 |
| 11412984 | 10.1016/s0960-894x(01)00184-6 | GABA-A receptor; alpha-1/beta-3/gamma-2 | 2 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| 38318365 | 10.1016/j.isci.2024.108907 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 1 |
| 18528996 | 10.1021/jm7015842 | Gamma-aminobutyric acid receptor subunit rho-1 | 1 |
| 21353350 | 10.1016/j.ejmech.2011.01.042 | Sodium- and chloride-dependent GABA transporter 1 | 1 |
| 3027337 | 10.1021/jm00385a003 | GABA-A receptor; anion channel | 1 |
| 10780899 | 10.1021/jm9904349 | Gamma-aminobutyric acid receptor subunit rho-2 | 1 |
Data from ChEMBL 36 via Core Engine