Assay Detail
Functional
CHEMBL894092
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at GABAC rho 1 receptor expressed in tsA-201 cells by FMP assay
14
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | tsA-201 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
5-Substituted imidazole-4-acetic acid analogues: synthesis, modeling, and pharmacological characterization of a series of novel gamma-aminobutyric acid(C) receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 5.71 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96 | GAMMA-AMINOBUTYRIC ACID | 1.0 | 2 | 6.40 |
| CHEMBL273481 | MUSCIMOL | 1.0 | 2 | 6.21 |
| CHEMBL784 | IMIDAZOLE ACETIC ACID | — | 2 | 5.30 |
| CHEMBL243929 | — | — | 2 | 5.00 |
| CHEMBL390012 | — | — | 2 | - |
| CHEMBL388249 | — | — | 2 | - |
| CHEMBL243932 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96 | GAMMA-AMINOBUTYRIC ACID | EC50 | = | 398.11 | nM | 6.40 |
| CHEMBL96 | GAMMA-AMINOBUTYRIC ACID | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL273481 | MUSCIMOL | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL273481 | MUSCIMOL | EC50 | = | 630.96 | nM | 6.20 |
| CHEMBL784 | IMIDAZOLE ACETIC ACID | EC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL784 | IMIDAZOLE ACETIC ACID | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL243929 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL243929 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL390012 | — | EC50 | = | 330000.0 | nM | - |
| CHEMBL390012 | — | EC50 | = | 316227.77 | nM | - |
| CHEMBL388249 | — | EC50 | = | 220000.0 | nM | - |
| CHEMBL388249 | — | EC50 | = | 199526.23 | nM | - |
| CHEMBL243932 | — | EC50 | = | 140000.0 | nM | - |
| CHEMBL243932 | — | EC50 | = | 158489.32 | nM | - |