Assay Detail
Functional
CHEMBL894096
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Agonist activity at human GABAC rho 1 receptor expressed in HEK293 cells by Whole-cell patch-clamp technique
6
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
5-Substituted imidazole-4-acetic acid analogues: synthesis, modeling, and pharmacological characterization of a series of novel gamma-aminobutyric acid(C) receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.00 | 5.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL784 | IMIDAZOLE ACETIC ACID | — | 2 | 5.26 |
| CHEMBL96 | GAMMA-AMINOBUTYRIC ACID | 1.0 | 2 | 5.22 |
| CHEMBL243929 | — | — | 2 | 4.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL784 | IMIDAZOLE ACETIC ACID | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL784 | IMIDAZOLE ACETIC ACID | EC50 | = | 5495.41 | nM | 5.26 |
| CHEMBL96 | GAMMA-AMINOBUTYRIC ACID | EC50 | = | 6025.6 | nM | 5.22 |
| CHEMBL96 | GAMMA-AMINOBUTYRIC ACID | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL243929 | — | EC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL243929 | — | EC50 | = | 31622.78 | nM | 4.50 |