Assay Detail
Functional
CHEMBL894097
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at rat GABA alpha-1-T129S-beta-2-gamma-2 receptor mutant expressed in HEK293 cells by Whole-cell patch-clamp technique
5
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
5-Substituted imidazole-4-acetic acid analogues: synthesis, modeling, and pharmacological characterization of a series of novel gamma-aminobutyric acid(C) receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 4.80 | 4.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96 | GAMMA-AMINOBUTYRIC ACID | 1.0 | 2 | 4.89 |
| CHEMBL784 | IMIDAZOLE ACETIC ACID | — | 2 | 4.70 |
| CHEMBL243929 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96 | GAMMA-AMINOBUTYRIC ACID | EC50 | = | 12882.5 | nM | 4.89 |
| CHEMBL96 | GAMMA-AMINOBUTYRIC ACID | EC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL784 | IMIDAZOLE ACETIC ACID | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL784 | IMIDAZOLE ACETIC ACID | EC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL243929 | — | EC50 | > | 1000000.0 | nM | - |