Assay Detail
Functional
CHEMBL894185
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Antiproliferative activity against Hs683 cells after 72 hrs by MTT assay
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Hs 683 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
2,2,2-Trichloro-N-({2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin- 5-yl}carbamoyl)acetamide (UNBS3157), a novel nonhematotoxic naphthalimide derivative with potent antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 5.36 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL244268 | — | — | 1 | 6.10 |
| CHEMBL244675 | — | — | 1 | 5.68 |
| CHEMBL394772 | — | — | 1 | 5.58 |
| CHEMBL244476 | — | — | 1 | 5.55 |
| CHEMBL244267 | — | — | 1 | 5.52 |
| CHEMBL244475 | — | — | 1 | 5.52 |
| CHEMBL390920 | — | — | 1 | 5.48 |
| CHEMBL390921 | — | — | 1 | 5.44 |
| CHEMBL43482 | MITONAFIDE | 2.0 | 1 | 5.43 |
| CHEMBL428676 | AMONAFIDE | 3.0 | 1 | 5.41 |
| CHEMBL244060 | — | — | 1 | 5.38 |
| CHEMBL541391 | — | — | 1 | 5.35 |
| CHEMBL394771 | — | — | 1 | 5.34 |
| CHEMBL538838 | — | — | 1 | 5.33 |
| CHEMBL243853 | — | — | 1 | 5.32 |
| CHEMBL534961 | — | — | 1 | 5.31 |
| CHEMBL243440 | — | — | 1 | 5.30 |
| CHEMBL244477 | — | — | 1 | 5.30 |
| CHEMBL396017 | — | — | 1 | 5.26 |
| CHEMBL244266 | — | — | 1 | 5.25 |
| CHEMBL244676 | — | — | 1 | 5.24 |
| CHEMBL243257 | — | — | 1 | 5.19 |
| CHEMBL20330 | — | — | 1 | 5.16 |
| CHEMBL244059 | — | — | 1 | 5.16 |
| CHEMBL556368 | — | — | 1 | 5.12 |
| CHEMBL244061 | — | — | 1 | 5.06 |
| CHEMBL397698 | — | — | 1 | 5.01 |
| CHEMBL390869 | — | — | 1 | - |
| CHEMBL396250 | — | — | 1 | - |
| CHEMBL428216 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL244268 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL244675 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL394772 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL244476 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL244267 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL244475 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL390920 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL390921 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL43482 | MITONAFIDE | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL428676 | AMONAFIDE | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL244060 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL541391 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL394771 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL538838 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL243853 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL534961 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL243440 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL244477 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL396017 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL244266 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL244676 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL243257 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL20330 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL244059 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL556368 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL244061 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL397698 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL2303804 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL243258 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL243259 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2303797 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL244677 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL390919 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL244508 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL243442 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL242178 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL243854 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL430191 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL242179 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL430189 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL390872 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL428216 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL396250 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL390869 | — | IC50 | > | 10000.0 | nM | - |