Assay Detail
Functional
CHEMBL894312
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 with RT L100I mutation by cytopathic cell killing assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis, biological activity, and crystal structure of potent nonnucleoside inhibitors of HIV-1 reverse transcriptase that retain activity against mutant forms of the enzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 6.47 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL292831 | — | — | 1 | 7.70 |
| CHEMBL58007 | — | — | 1 | 7.17 |
| CHEMBL57770 | — | — | 1 | 7.10 |
| CHEMBL294004 | — | — | 1 | 7.10 |
| CHEMBL292923 | — | — | 1 | 6.80 |
| CHEMBL293961 | — | — | 1 | 6.52 |
| CHEMBL291505 | — | — | 1 | 6.52 |
| CHEMBL61352 | — | — | 1 | 6.30 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.14 |
| CHEMBL293984 | — | — | 1 | 5.92 |
| CHEMBL58494 | — | — | 1 | 5.78 |
| CHEMBL418637 | — | — | 1 | 5.61 |
| CHEMBL58358 | — | — | 1 | 5.49 |
| CHEMBL56435 | — | — | 1 | - |
| CHEMBL59448 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL292831 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL58007 | — | EC50 | = | 68.0 | nM | 7.17 |
| CHEMBL57770 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL294004 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL292923 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL293961 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL291505 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL61352 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 720.0 | nM | 6.14 |
| CHEMBL293984 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL58494 | — | EC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL418637 | — | EC50 | = | 2480.0 | nM | 5.61 |
| CHEMBL58358 | — | EC50 | = | 3250.0 | nM | 5.49 |
| CHEMBL56435 | — | EC50 | - | — | - | |
| CHEMBL59448 | — | EC50 | - | — | - |