Assay Detail
Binding
CHEMBL894326
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Inhibition of SARS coronavirus 3CL protease
12
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome-related coronavirus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1a (CHEMBL3927) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome-related coronavirus |
Publication
Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.07 | 5.09 |
| IC50 | 6 | 4.60 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269277 | BETULINIC ACID | 1.0 | 2 | 5.09 |
| CHEMBL395263 | SAVININ | — | 2 | 5.04 |
| CHEMBL1448 | NICLOSAMIDE | 4.0 | 2 | 4.40 |
| CHEMBL140 | CURCUMIN | 3.0 | 2 | 4.40 |
| CHEMBL242011 | HINOKININ | — | 2 | - |
| CHEMBL431525 | BETUNOLIC ACID | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269277 | BETULINIC ACID | Ki | = | 8200.0 | nM | 5.09 |
| CHEMBL395263 | SAVININ | Ki | = | 9100.0 | nM | 5.04 |
| CHEMBL269277 | BETULINIC ACID | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL395263 | SAVININ | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL1448 | NICLOSAMIDE | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL140 | CURCUMIN | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL1448 | NICLOSAMIDE | Ki | - | — | - | |
| CHEMBL140 | CURCUMIN | Ki | - | — | - | |
| CHEMBL242011 | HINOKININ | Ki | - | — | - | |
| CHEMBL242011 | HINOKININ | IC50 | > | 100000.0 | nM | - |
| CHEMBL431525 | BETUNOLIC ACID | Ki | - | — | - | |
| CHEMBL431525 | BETUNOLIC ACID | IC50 | > | 100000.0 | nM | - |